Simulation scenario 10, CR phase

Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.114, shape = 1.05	scale = 0.124, shape = 1.05	scale = 0.124, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.7, median = 6.3	mean = 8.6, median = 6.2	mean = 7.9, median = 5.7	mean = 7.9, median = 5.7
	effect	af = 1, hr = 1	af = 0.99, hr = 1.01	af = 0.98, hr = 1.02	af = 0.9, hr = 1.12	af = 0.9, hr = 1.12
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.128, shape = 1.05	scale = 0.127, shape = 1.05	scale = 0.127, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 7.7, median = 5.5	mean = 7.7, median = 5.5	mean = 7.7, median = 5.5
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 0.87, hr = 1.15	af = 0.88, hr = 1.15	af = 0.88, hr = 1.15
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.105, shape = 1.05	scale = 0.125, shape = 1.05	scale = 0.125, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 9.3, median = 6.7	mean = 7.8, median = 5.6	mean = 7.8, median = 5.6
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 1.06, hr = 0.94	af = 0.89, hr = 1.13	af = 0.89, hr = 1.13
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.117, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.4, median = 6	mean = 9.9, median = 7.1	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.95, hr = 1.05	af = 1.13, hr = 0.88	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.127, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 7.7, median = 5.6	mean = 25, median = 18	mean = 8.7, median = 6.3	mean = 8.7, median = 6.3
	effect	af = 1, hr = 1	af = 0.88, hr = 1.14	af = 2.85, hr = 0.33	af = 0.99, hr = 1.01	af = 0.99, hr = 1.01

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
—+	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
–+-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
–++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
-+–	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.043, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 22.6, median = 16.3	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 2.58, hr = 0.37	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+–+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
+-++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43
++–	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 6.3, median = 4.5	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 0.71, hr = 1.43	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.157, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 6.3, median = 4.5	mean = 25, median = 18	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 0.71, hr = 1.43	af = 2.85, hr = 0.33	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 6 5 1 1 TP53- & AR- 240 0 0 1 TP53+ 1 16 1 1 DRD+ 0 1 120 132 TEfus+ 0 163 0 1

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.012 0.010 0.002 0.002 TP53- & AR- 0.480 0.000 0.000 0.002 TP53+ 0.002 0.032 0.002 0.002 DRD+ 0.000 0.002 0.240 0.264 TEfus+ 0.000 0.326 0.000 0.002

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 1 1 TP53- & AR- 1 118 138 119 TP53+ 237 1 0 4 DRD+ 116 10 0 0 TEfus+ 107 0 14 13

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.002 0.002 TP53- & AR- 0.002 0.236 0.276 0.238 TP53+ 0.474 0.002 0.000 0.008 DRD+ 0.232 0.020 0.000 0.000 TEfus+ 0.214 0.000 0.028 0.026

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 3 17 15 23 TP53+ 0 8 17 11 DRD+ 0 0 0 0 TEfus+ 0 0 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.006 0.034 0.030 0.046 TP53+ 0.000 0.016 0.034 0.022 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.000

Errors & power

The overall error was 0.056.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.012             0.034             0.004             0.006 

The overall power was 0.798.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.480             0.326             0.240             0.264 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	6	5	1	1
	futility	0	0	0	1	1
	max_n	0	0	0	0	0
	n	276 (245, 318)	181 (121, 251)	235 (173, 292)	246 (183, 291)	247 (185, 292)
	n_unique	252 (223, 291)	164 (109, 231)	215 (156, 264)	224 (166, 268)	225 (167, 266)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	4 (4, 5)	6 (4, 7)	5 (5, 5)	4 (4, 5)
	post_p	NA (NA, NA)	0.57 (0.04, 0.98)	0.58 (0.05, 0.96)	0.29 (0.02, 0.78)	0.22 (0.02, 0.7)
	rate	0.094 (0.085, 0.104)	0.09 (0.074, 0.112)	0.091 (0.079, 0.109)	0.1 (0.089, 0.113)	0.101 (0.09, 0.115)
TP53- & AR-	graduation	0	240	0	0	1
	futility	0	1	118	138	119
	max_n	0	3	17	15	23
	n	116 (95, 145)	77 (26, 116)	98 (32, 130)	97 (31, 132)	99 (29, 135)
	n_unique	108 (87, 135)	72 (24, 105)	89 (29, 118)	89 (29, 122)	91 (27, 123)
	time_trial	36 (36, 36)	36 (10, 36)	36 (13, 36)	36 (12, 36)	36 (12, 36)
	time_stop	NA (NA, NA)	13 (9, 29)	14 (9, 27)	14 (9, 23)	13 (9, 20)
	post_p	NA (NA, NA)	1 (0.93, 1)	0.02 (0, 0.18)	0.03 (0, 0.26)	0.03 (0, 0.24)
	rate	0.073 (0.063, 0.086)	0.043 (0.034, 0.052)	0.109 (0.091, 0.134)	0.105 (0.088, 0.134)	0.105 (0.089, 0.132)
TP53+	graduation	0	1	16	1	1
	futility	0	237	1	0	4
	max_n	0	0	8	17	11
	n	119 (103, 143)	87 (29, 119)	108 (76, 133)	115 (94, 138)	114 (94, 136)
	n_unique	108 (94, 131)	78 (27, 107)	98 (68, 120)	104 (85, 125)	103 (84, 123)
	time_trial	36 (36, 36)	36 (11, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	17 (9, 32)	11 (8, 18)	9 (9, 9)	10 (10, 16)
	post_p	NA (NA, NA)	0.02 (0, 0.16)	0.97 (0.61, 1)	0.72 (0.22, 0.97)	0.66 (0.21, 0.96)
	rate	0.113 (0.097, 0.131)	0.159 (0.138, 0.197)	0.084 (0.068, 0.103)	0.103 (0.086, 0.122)	0.105 (0.089, 0.123)
DRD+	graduation	0	0	1	120	132
	futility	0	116	10	0	0
	max_n	0	0	0	0	0
	n	80 (65, 99)	49 (28, 77)	67 (43, 91)	69 (33, 91)	68 (32, 89)
	n_unique	74 (59, 92)	44 (25, 68)	59 (38, 81)	62 (29, 81)	61 (30, 81)
	time_trial	36 (36, 36)	36 (18, 36)	36 (36, 36)	36 (19, 36)	36 (18, 36)
	time_stop	NA (NA, NA)	19 (13, 26)	16 (13, 23)	22 (13, 33)	21 (13, 33)
	post_p	NA (NA, NA)	0.21 (0.02, 0.71)	0.57 (0.12, 0.94)	1 (0.99, 1)	1 (0.99, 1)
	rate	0.091 (0.074, 0.111)	0.098 (0.073, 0.129)	0.078 (0.062, 0.1)	0.036 (0.027, 0.045)	0.037 (0.028, 0.045)
TEfus+	graduation	0	0	163	0	1
	futility	0	107	0	14	13
	max_n	0	0	0	0	0
	n	105 (87, 128)	69 (34, 99)	86 (27, 112)	94 (72, 117)	94 (69, 118)
	n_unique	96 (79, 118)	61 (30, 89)	77 (25, 101)	85 (65, 105)	85 (62, 107)
	time_trial	36 (36, 36)	36 (16, 36)	36 (12, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	16 (11, 33)	15 (9, 31)	16 (13, 28)	14 (11, 25)
	post_p	NA (NA, NA)	0.03 (0, 0.3)	1 (0.98, 1)	0.18 (0.01, 0.62)	0.14 (0.01, 0.58)
	rate	0.074 (0.062, 0.088)	0.108 (0.083, 0.136)	0.038 (0.03, 0.046)	0.086 (0.072, 0.107)	0.089 (0.074, 0.109)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	247	123	140	122
	futility	0	0	0	0	0
	max_n	0	3	17	15	23
	n	70 (55, 89)	50 (16, 73)	62 (20, 83)	60 (20, 82)	60 (20, 84)
	n_unique	64 (50, 85)	47 (15, 68)	58 (19, 78)	56 (19, 77)	56 (19, 78)
	post_p	NA (NA, NA)	1 (0.95, 1)	0 (0, 0.06)	0 (0, 0.06)	0 (0, 0.07)
	rate	0.083 (0.069, 0.102)	0.043 (0.033, 0.057)	0.159 (0.134, 0.194)	0.161 (0.133, 0.198)	0.158 (0.132, 0.191)
—+	graduation	0	318	253	148	130
	futility	0	0	0	0	0
	max_n	0	3	17	15	23
	n	15 (9, 22)	7 (2, 17)	10 (2, 18)	12 (4, 19)	14 (4, 20)
	n_unique	14 (9, 21)	6 (2, 16)	9 (2, 16)	11 (3, 17)	12 (4, 19)
	post_p	NA (NA, NA)	0.76 (0.38, 0.95)	0.81 (0.46, 0.98)	0.06 (0, 0.24)	0.05 (0, 0.22)
	rate	0.052 (0.031, 0.082)	0.042 (0.02, 0.089)	0.038 (0.02, 0.075)	0.161 (0.111, 0.25)	0.164 (0.112, 0.242)
–+-	graduation	0	244	22	3	7
	futility	0	0	0	0	0
	max_n	0	0	8	17	11
	n	38 (29, 48)	29 (10, 42)	36 (29, 46)	37 (29, 46)	37 (29, 47)
	n_unique	35 (26, 43)	26 (9, 39)	34 (26, 42)	34 (26, 43)	34 (27, 43)
	post_p	NA (NA, NA)	0.42 (0.1, 0.8)	0.4 (0.08, 0.81)	0.43 (0.11, 0.82)	0.38 (0.07, 0.76)
	rate	0.147 (0.118, 0.184)	0.164 (0.127, 0.22)	0.159 (0.126, 0.201)	0.157 (0.126, 0.199)	0.164 (0.13, 0.205)
–++	graduation	0	294	181	17	20
	futility	0	0	0	0	0
	max_n	0	0	8	17	11
	n	27 (20, 36)	17 (6, 28)	22 (8, 31)	27 (18, 35)	26 (18, 35)
	n_unique	25 (18, 33)	16 (6, 26)	19 (7, 28)	24 (16, 32)	24 (16, 32)
	post_p	NA (NA, NA)	0.1 (0.01, 0.35)	0.99 (0.92, 1)	0.06 (0, 0.28)	0.05 (0, 0.26)
	rate	0.087 (0.062, 0.119)	0.163 (0.117, 0.234)	0.037 (0.023, 0.056)	0.158 (0.122, 0.204)	0.161 (0.123, 0.216)
-+–	graduation	0	333	131	245	235
	futility	0	0	0	0	0
	max_n	0	3	17	14	21
	n	15 (10, 22)	8 (2, 17)	13 (4, 20)	10 (3, 19)	11 (3, 19)
	n_unique	14 (9, 20)	7 (2, 15)	12 (4, 18)	9 (2, 17)	10 (2, 17)
	post_p	NA (NA, NA)	0.76 (0.4, 0.96)	0.06 (0, 0.3)	0.83 (0.46, 0.98)	0.83 (0.48, 0.98)
	rate	0.083 (0.053, 0.132)	0.043 (0.019, 0.08)	0.161 (0.109, 0.243)	0.036 (0.019, 0.078)	0.038 (0.02, 0.076)
-+-+	graduation	0	373	259	253	242
	futility	0	0	0	0	0
	max_n	0	3	17	14	21
	n	16 (10, 22)	6 (2, 17)	10 (2, 19)	11 (3, 20)	12 (3, 20)
	n_unique	14 (8, 21)	5 (2, 16)	9 (2, 17)	10 (3, 18)	11 (3, 18)
	post_p	NA (NA, NA)	0.52 (0.25, 0.78)	0.57 (0.3, 0.84)	0.59 (0.29, 0.86)	0.6 (0.32, 0.87)
	rate	0.054 (0.032, 0.086)	0.043 (0.02, 0.077)	0.04 (0.019, 0.074)	0.037 (0.019, 0.071)	0.038 (0.02, 0.069)
-++-	graduation	0	303	33	121	139
	futility	0	0	0	0	0
	max_n	0	0	8	15	11
	n	8 (5, 13)	5 (2, 10)	8 (4, 12)	7 (3, 12)	7 (3, 11)
	n_unique	7 (4, 12)	4 (1, 9)	7 (3, 11)	6 (2, 11)	6 (2, 10)
	post_p	NA (NA, NA)	0.29 (0.12, 0.55)	0.26 (0.06, 0.54)	0.89 (0.67, 0.98)	0.9 (0.65, 0.98)
	rate	0.15 (0.092, 0.263)	0.171 (0.089, 0.356)	0.16 (0.096, 0.278)	0.035 (0.012, 0.07)	0.035 (0.012, 0.074)
-+++	graduation	0	336	190	135	151
	futility	0	0	0	0	0
	max_n	0	0	8	15	11
	n	8 (4, 13)	5 (1, 9)	6 (2, 12)	8 (3, 12)	7 (2, 12)
	n_unique	7 (4, 12)	4 (1, 8)	5 (1, 11)	7 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.21 (0.05, 0.39)	0.7 (0.43, 0.9)	0.69 (0.43, 0.92)	0.72 (0.45, 0.92)
	rate	0.091 (0.045, 0.179)	0.169 (0.095, 0.391)	0.037 (0.014, 0.08)	0.036 (0.016, 0.073)	0.034 (0.013, 0.072)
+—	graduation	0	6	5	2	2
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (7, 17)	12 (7, 17)	12 (8, 17)	12 (8, 17)	12 (7, 17)
	n_unique	10 (7, 15)	11 (6, 15)	11 (7, 15)	10 (6, 15)	11 (6, 16)
	post_p	NA (NA, NA)	0.47 (0.16, 0.8)	0.46 (0.14, 0.82)	0.45 (0.16, 0.82)	0.47 (0.17, 0.79)
	rate	0.149 (0.095, 0.233)	0.159 (0.11, 0.244)	0.162 (0.106, 0.255)	0.163 (0.108, 0.245)	0.16 (0.108, 0.236)
+–+	graduation	0	113	168	16	16
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	10 (6, 15)	9 (4, 14)	8 (3, 14)	10 (6, 15)	10 (6, 15)
	n_unique	9 (5, 14)	8 (3, 13)	8 (3, 13)	9 (5, 13)	9 (5, 14)
	post_p	NA (NA, NA)	0.23 (0.06, 0.51)	0.94 (0.73, 0.99)	0.23 (0.06, 0.51)	0.21 (0.05, 0.52)
	rate	0.088 (0.048, 0.156)	0.169 (0.107, 0.274)	0.039 (0.016, 0.067)	0.162 (0.107, 0.256)	0.167 (0.105, 0.261)
+-+-	graduation	0	244	22	3	7
	futility	0	0	0	0	0
	max_n	0	0	8	17	11
	n	10 (6, 14)	7 (2, 13)	10 (6, 15)	10 (6, 14)	10 (6, 15)
	n_unique	9 (5, 13)	6 (2, 12)	9 (5, 14)	9 (5, 13)	9 (5, 14)
	post_p	NA (NA, NA)	0.44 (0.18, 0.78)	0.47 (0.13, 0.8)	0.49 (0.18, 0.81)	0.49 (0.19, 0.8)
	rate	0.153 (0.093, 0.238)	0.175 (0.108, 0.368)	0.166 (0.105, 0.27)	0.159 (0.102, 0.249)	0.16 (0.103, 0.244)
+-++	graduation	0	294	181	17	20
	futility	0	0	0	0	0
	max_n	0	0	8	17	11
	n	11 (7, 17)	7 (2, 13)	9 (3, 14)	10 (6, 16)	10 (6, 16)
	n_unique	10 (6, 15)	6 (2, 12)	8 (2, 13)	9 (5, 15)	9 (5, 15)
	post_p	NA (NA, NA)	0.26 (0.07, 0.53)	0.93 (0.67, 0.99)	0.2 (0.04, 0.5)	0.2 (0.04, 0.46)
	rate	0.087 (0.049, 0.148)	0.168 (0.102, 0.36)	0.04 (0.017, 0.08)	0.158 (0.108, 0.264)	0.164 (0.11, 0.26)
++–	graduation	0	122	16	122	134
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	8 (4, 12)	6 (2, 11)	7 (4, 12)	7 (3, 12)	7 (3, 11)
	n_unique	7 (4, 11)	6 (2, 10)	7 (3, 11)	6 (3, 10)	6 (2, 10)
	post_p	NA (NA, NA)	0.28 (0.09, 0.51)	0.25 (0.08, 0.52)	0.89 (0.65, 0.99)	0.89 (0.64, 0.98)
	rate	0.153 (0.091, 0.258)	0.165 (0.104, 0.307)	0.162 (0.094, 0.296)	0.036 (0.013, 0.07)	0.036 (0.013, 0.074)
++-+	graduation	0	191	177	136	147
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	8 (4, 13)	6 (2, 11)	6 (2, 11)	7 (3, 12)	7 (3, 11)
	n_unique	7 (4, 12)	6 (2, 10)	6 (2, 10)	6 (2, 11)	6 (2, 10)
	post_p	NA (NA, NA)	0.17 (0.04, 0.37)	0.7 (0.43, 0.9)	0.74 (0.47, 0.92)	0.74 (0.48, 0.91)
	rate	0.095 (0.049, 0.167)	0.168 (0.102, 0.329)	0.04 (0.014, 0.081)	0.035 (0.014, 0.071)	0.035 (0.014, 0.072)
+++-	graduation	0	303	33	121	139
	futility	0	0	0	0	0
	max_n	0	0	8	15	11
	n	8 (5, 13)	5 (2, 10)	8 (4, 12)	7 (3, 12)	7 (3, 12)
	n_unique	7 (4, 12)	4 (1, 9)	7 (3, 11)	6 (3, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.29 (0.1, 0.49)	0.26 (0.08, 0.52)	0.89 (0.64, 0.99)	0.89 (0.68, 0.98)
	rate	0.151 (0.09, 0.265)	0.175 (0.102, 0.368)	0.162 (0.097, 0.283)	0.037 (0.015, 0.079)	0.039 (0.014, 0.073)
++++	graduation	0	336	190	135	151
	futility	0	0	0	0	0
	max_n	0	0	8	15	11
	n	8 (5, 13)	5 (1, 10)	6 (2, 12)	7 (3, 13)	7 (3, 12)
	n_unique	8 (4, 13)	4 (1, 9)	5 (1, 11)	7 (3, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.22 (0.05, 0.4)	0.69 (0.45, 0.89)	0.73 (0.48, 0.93)	0.7 (0.44, 0.91)
	rate	0.088 (0.047, 0.159)	0.168 (0.099, 0.365)	0.039 (0.015, 0.078)	0.033 (0.013, 0.071)	0.037 (0.015, 0.07)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	6	5	1	1
	time_stop	4 (4, 5)	6 (4, 7)	5 (5, 5)	4 (4, 4)
	n_trt	26 (25, 28)	36 (34, 45)	38 (38, 38)	29 (29, 29)
	n_control	28 (16, 38)	39 (26, 43)	29 (29, 29)	23 (23, 23)
	post_p	0.88 (0.86, 0.96)	0.93 (0.88, 0.96)	0.96 (0.96, 0.96)	0.98 (0.98, 0.98)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)
TP53- & AR-	count	240			1
	time_stop	13 (9, 29)			9 (9, 9)
	n_trt	31 (25, 83)			25 (25, 25)
	n_control	34 (21, 86)			22 (22, 22)
	post_p	0.98 (0.91, 1)			0.92 (0.92, 0.92)
	order	1 (1, 2)			1 (1, 1)
TP53+	count	1	16	1	1
	time_stop	9 (9, 9)	11 (8, 18)	9 (9, 9)	10 (10, 10)
	n_trt	29 (29, 29)	31 (25, 56)	26 (26, 26)	26 (26, 26)
	n_control	23 (23, 23)	36 (22, 64)	27 (27, 27)	37 (37, 37)
	post_p	0.86 (0.86, 0.86)	0.97 (0.89, 1)	0.97 (0.97, 0.97)	0.98 (0.98, 0.98)
	order	1 (1, 1)	1 (1, 2.5)	1 (1, 1)	2 (2, 2)
DRD+	count		1	120	132
	time_stop		13 (13, 13)	22 (13, 33)	21 (13, 33)
	n_trt		26 (26, 26)	38 (25, 77)	38 (25, 72)
	n_control		16 (16, 16)	42 (24, 77)	44 (24, 73)
	post_p		0.92 (0.92, 0.92)	1 (0.98, 1)	1 (0.98, 1)
	order		1 (1, 1)	2 (1, 3)	2 (1, 3)
TEfus+	count		163		1
	time_stop		15 (9, 31)		11 (11, 11)
	n_trt		34 (26, 81)		26 (26, 26)
	n_control		37 (21, 88)		27 (27, 27)
	post_p		0.99 (0.94, 1)		0.97 (0.97, 0.97)
	order		1 (1, 2)		2 (2, 2)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count			1	1
	time_stop			5 (5, 5)	5 (5, 5)
	n_trt			37 (37, 37)	26 (26, 26)
	n_control			34 (34, 34)	42 (42, 42)
	post_p			0.17 (0.17, 0.17)	0.16 (0.16, 0.16)
	order			1 (1, 1)	1 (1, 1)
TP53- & AR-	count	1	118	138	119
	time_stop	7 (7, 7)	14 (9, 27)	14 (9, 23)	13 (9, 20)
	n_trt	28 (28, 28)	37 (26, 70)	36 (26, 67)	34 (25, 61)
	n_control	14 (14, 14)	37 (22, 73)	36 (21, 67)	35 (22, 57)
	post_p	0.27 (0.27, 0.27)	0.07 (0, 0.21)	0.08 (0, 0.23)	0.1 (0.01, 0.24)
	order	1 (1, 1)	1 (1, 3)	1 (1, 3)	1 (1, 3)
TP53+	count	237	1		4
	time_stop	17 (9, 32)	11 (11, 11)		11 (10, 16)
	n_trt	49 (27, 97)	29 (29, 29)		32 (29, 45)
	n_control	49 (25, 99)	27 (27, 27)		44 (32, 62)
	post_p	0.03 (0, 0.14)	0.08 (0.08, 0.08)		0.09 (0.05, 0.22)
	order	2 (1, 3)	2 (2, 2)		1.5 (1, 2.7)
DRD+	count	116	10
	time_stop	19 (13, 26)	16 (13, 24)
	n_trt	32 (26, 50)	33 (29, 49)
	n_control	37 (22, 55)	30 (22, 54)
	post_p	0.05 (0, 0.17)	0.07 (0.02, 0.2)
	order	2 (1, 3)	2 (1, 4)
TEfus+	count	107		14	13
	time_stop	16 (11, 33)		16 (13, 28)	14 (12, 26)
	n_trt	39 (26, 64)		34 (30, 65)	36 (27, 66)
	n_control	44 (25, 94)		42 (32, 74)	37 (28, 55)
	post_p	0.02 (0, 0.1)		0.04 (0, 0.14)	0.02 (0, 0.2)
	order	2 (1, 3)		2 (1, 3)	3 (1, 3)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
		time	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)
		n	7 (5, 9)	2 (0, 3)	4 (2, 6)	2 (1, 2)	1 (0, 2)	2 (0, 2)	1 (0, 2)	0 (0, 2)	2 (1, 2)	0 (0, 2)	0 (0, 2)	2 (0, 2)	1 (0, 2)	1 (0, 2)	2 (0, 2)	0 (0, 0)
		post_p	0.63 (0.54, 0.76)	0.54 (0.52, 0.56)	0.57 (0.54, 0.81)	0.56 (0.55, 0.59)	0.56 (0.52, 0.56)	0.53 (0.51, 0.55)	0.52 (0.52, 0.52)	NA (NA, NA)	0.51 (0.5, 0.62)	NA (NA, NA)	0.57 (0.57, 0.57)	0.54 (0.53, 0.55)	0.53 (0.53, 0.53)	0.53 (0.51, 0.56)	0.54 (0.53, 0.55)	0.5 (0.5, 0.5)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0 (0, 0.079)	0 (0, 0)	0 (0, 0.14)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.087 (0.017, 0.157)	0 (0, 0)	0 (0, 0.234)	0.157 (0.031, 0.325)	0 (0, 0)	0.194 (0, 0.653)	0 (0, 0)	0.079 (0, 0.236)	0 (0, 0)
	Taxel_therapies	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
		time	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)	6 (4, 7)
		n	9 (8, 14)	1 (0, 2)	7 (2, 8)	3 (1, 7)	3 (0, 4)	1 (0, 2)	0 (0, 2)	1 (0, 2)	3 (2, 5)	1 (0, 4)	0 (0, 3)	3 (0, 4)	1 (0, 2)	0 (0, 2)	0 (0, 2)	2 (0, 3)
		post_p	0.56 (0.55, 0.72)	0.54 (0.53, 0.55)	0.61 (0.53, 0.66)	0.58 (0.55, 0.61)	0.54 (0.52, 0.56)	0.51 (0.5, 0.53)	0.56 (0.56, 0.56)	0.53 (0.52, 0.54)	0.6 (0.51, 0.66)	0.52 (0.51, 0.59)	0.54 (0.52, 0.55)	0.55 (0.52, 0.62)	0.52 (0.52, 0.55)	0.52 (0.51, 0.54)	0.51 (0.51, 0.52)	0.53 (0.5, 0.59)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.086 (0.051, 0.11)	0 (0, 0)	0.031 (0, 0.085)	0 (0, 0)	0 (0, 0.041)	0 (0, 0)	0.186 (0.186, 0.186)	0 (0, 0)	0.078 (0, 0.311)	0 (0, 0)	0.085 (0.017, 0.153)	0 (0, 0.076)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
		n	9 (9, 9)	0 (0, 0)	3 (3, 3)	6 (6, 6)	4 (4, 4)	2 (2, 2)	0 (0, 0)	1 (1, 1)	1 (1, 1)	1 (1, 1)	3 (3, 3)	1 (1, 1)	0 (0, 0)	3 (3, 3)	3 (3, 3)	1 (1, 1)
		post_p	0.56 (0.56, 0.56)	NA (NA, NA)	0.55 (0.55, 0.55)	0.5 (0.5, 0.5)	0.53 (0.53, 0.53)	0.55 (0.55, 0.55)	NA (NA, NA)	0.51 (0.51, 0.51)	0.58 (0.58, 0.58)	0.53 (0.53, 0.53)	0.55 (0.55, 0.55)	0.57 (0.57, 0.57)	NA (NA, NA)	0.55 (0.55, 0.55)	0.6 (0.6, 0.6)	0.51 (0.51, 0.51)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.147 (0.147, 0.147)	NA (NA, NA)	0.113 (0.113, 0.113)	0.066 (0.066, 0.066)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.396 (0.396, 0.396)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	3 (3, 3)	0 (0, 0)	8 (8, 8)	2 (2, 2)	1 (1, 1)	2 (2, 2)	2 (2, 2)	0 (0, 0)	1 (1, 1)	0 (0, 0)	5 (5, 5)	0 (0, 0)	0 (0, 0)	1 (1, 1)	4 (4, 4)	0 (0, 0)
		post_p	0.56 (0.56, 0.56)	NA (NA, NA)	0.65 (0.65, 0.65)	0.55 (0.55, 0.55)	0.51 (0.51, 0.51)	0.51 (0.51, 0.51)	0.54 (0.54, 0.54)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	0.63 (0.63, 0.63)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	NA (NA, NA)	0.069 (0.069, 0.069)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0.069 (0.069, 0.069)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)
TP53- & AR-	Hormone_therapies	count	240	240			240	240
		time	13 (9, 29)	13 (9, 29)			13 (9, 29)	13 (9, 29)
		n	21 (15, 52)	4 (2, 12)			4 (2, 11)	4 (1, 13)
		post_p	0.96 (0.83, 1)	0.63 (0.53, 0.87)			0.61 (0.52, 0.81)	0.56 (0.51, 0.76)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.039 (0.018, 0.062)	0.024 (0, 0.071)			0.017 (0, 0.068)	0 (0, 0.047)
	Niraparib	count	1	1			1	1
		time	9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)
		n	19 (19, 19)	3 (3, 3)			2 (2, 2)	1 (1, 1)
		post_p	0.83 (0.83, 0.83)	0.75 (0.75, 0.75)			0.52 (0.52, 0.52)	0.51 (0.51, 0.51)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.055 (0.055, 0.055)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)
TP53+	Hormone_therapies	count			1	1			1	1			1	1			1	1
		time			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)
		n			10 (10, 10)	9 (9, 9)			2 (2, 2)	2 (2, 2)			1 (1, 1)	2 (2, 2)			1 (1, 1)	2 (2, 2)
		post_p			0.73 (0.73, 0.73)	0.74 (0.74, 0.74)			0.52 (0.52, 0.52)	NA (NA, NA)			0.52 (0.52, 0.52)	NA (NA, NA)			NA (NA, NA)	0.52 (0.52, 0.52)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.093 (0.093, 0.093)	0.042 (0.042, 0.042)			0 (0, 0)	0.257 (0.257, 0.257)			0 (0, 0)	0.29 (0.29, 0.29)			1.078 (1.078, 1.078)	0 (0, 0)
	Taxel_therapies	count			16	16			16	16			16	16			16	16
		time			11 (8, 18)	11 (8, 18)			11 (8, 18)	11 (8, 18)			11 (8, 18)	11 (8, 18)			11 (8, 18)	11 (8, 18)
		n			11 (7, 20)	8 (4, 12)			1 (0, 4)	2 (0, 6)			3 (2, 7)	3 (1, 6)			2 (0, 4)	3 (0, 5)
		post_p			0.77 (0.7, 0.86)	0.85 (0.71, 0.96)			0.53 (0.51, 0.63)	0.54 (0.52, 0.74)			0.64 (0.54, 0.8)	0.62 (0.54, 0.95)			0.55 (0.51, 0.66)	0.55 (0.52, 0.6)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.086 (0.057, 0.133)	0.021 (0, 0.055)			0 (0, 0.093)	0 (0, 0.083)			0.087 (0, 0.145)	0 (0, 0.04)			0 (0, 0.126)	0 (0, 0.037)
	Carboplatin	count			1	1			1	1			1	1			1	1
		time			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)
		n			7 (7, 7)	5 (5, 5)			3 (3, 3)	2 (2, 2)			2 (2, 2)	2 (2, 2)			3 (3, 3)	2 (2, 2)
		post_p			0.81 (0.81, 0.81)	0.55 (0.55, 0.55)			0.74 (0.74, 0.74)	0.53 (0.53, 0.53)			0.68 (0.68, 0.68)	0.53 (0.53, 0.53)			0.52 (0.52, 0.52)	0.56 (0.56, 0.56)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.074 (0.074, 0.074)	0.043 (0.043, 0.043)			0 (0, 0)	0 (0, 0)			0.109 (0.109, 0.109)	0 (0, 0)			0 (0, 0)	0 (0, 0)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)
		n			8 (8, 8)	4 (4, 4)			5 (5, 5)	1 (1, 1)			2 (2, 2)	3 (3, 3)			2 (2, 2)	1 (1, 1)
		post_p			0.96 (0.96, 0.96)	0.61 (0.61, 0.61)			0.74 (0.74, 0.74)	0.52 (0.52, 0.52)			0.5 (0.5, 0.5)	0.53 (0.53, 0.53)			0.57 (0.57, 0.57)	0.54 (0.54, 0.54)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.057 (0.057, 0.057)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.218 (0.218, 0.218)	0.125 (0.125, 0.125)			0 (0, 0)	0 (0, 0)
DRD+	Taxel_therapies	count					1	1	1	1					1	1	1	1
		time					13 (13, 13)	13 (13, 13)	13 (13, 13)	13 (13, 13)					13 (13, 13)	13 (13, 13)	13 (13, 13)	13 (13, 13)
		n					4 (4, 4)	5 (5, 5)	5 (5, 5)	3 (3, 3)					1 (1, 1)	4 (4, 4)	1 (1, 1)	3 (3, 3)
		post_p					0.56 (0.56, 0.56)	0.55 (0.55, 0.55)	0.69 (0.69, 0.69)	0.55 (0.55, 0.55)					0.54 (0.54, 0.54)	0.52 (0.52, 0.52)	0.54 (0.54, 0.54)	0.64 (0.64, 0.64)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.054 (0.054, 0.054)	0.029 (0.029, 0.029)	0 (0, 0)	0.056 (0.056, 0.056)					0 (0, 0)	0.101 (0.101, 0.101)	0 (0, 0)	0.056 (0.056, 0.056)
	Carboplatin	count					120	120	120	120					120	120	120	120
		time					22 (13, 33)	22 (13, 33)	22 (13, 33)	22 (13, 33)					22 (13, 33)	22 (13, 33)	22 (13, 33)	22 (13, 33)
		n					6 (3, 16)	6 (3, 15)	4 (1, 9)	4 (1, 10)					4 (2, 8)	4 (2, 9)	5 (2, 10)	4 (2, 9)
		post_p					0.73 (0.54, 0.95)	0.71 (0.52, 0.85)	0.73 (0.57, 0.94)	0.66 (0.53, 0.83)					0.75 (0.54, 0.93)	0.67 (0.53, 0.87)	0.78 (0.57, 0.96)	0.69 (0.53, 0.84)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.026 (0, 0.052)	0.026 (0, 0.048)	0.03 (0, 0.071)	0.021 (0, 0.057)					0.028 (0, 0.087)	0.021 (0, 0.067)	0.03 (0, 0.07)	0.022 (0, 0.062)
	Niraparib	count					132	132	132	132					132	132	132	132
		time					21 (13, 33)	21 (13, 33)	21 (13, 33)	21 (13, 33)					21 (13, 33)	21 (13, 33)	21 (13, 33)	21 (13, 33)
		n					8 (3, 14)	5 (3, 16)	4 (2, 9)	4 (1, 9)					4 (2, 8)	4 (2, 8)	4 (2, 8)	4 (2, 8)
		post_p					0.76 (0.55, 0.94)	0.71 (0.52, 0.82)	0.73 (0.55, 0.93)	0.64 (0.52, 0.87)					0.72 (0.53, 0.91)	0.65 (0.53, 0.88)	0.72 (0.58, 0.94)	0.64 (0.52, 0.85)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.026 (0, 0.056)	0.022 (0, 0.04)	0.029 (0, 0.071)	0.022 (0, 0.064)					0.029 (0, 0.08)	0.019 (0, 0.056)	0.029 (0, 0.074)	0.021 (0, 0.063)
TEfus+	Taxel_therapies	count		163		163		163		163		163		163		163		163
		time		15 (9, 31)		15 (9, 31)		15 (9, 31)		15 (9, 31)		15 (9, 31)		15 (9, 31)		15 (9, 31)		15 (9, 31)
		n		5 (2, 12)		11 (6, 23)		4 (2, 13)		3 (1, 7)		4 (1, 10)		4 (2, 10)		3 (1, 7)		3 (1, 9)
		post_p		0.69 (0.54, 0.9)		0.92 (0.75, 1)		0.58 (0.51, 0.78)		0.59 (0.52, 0.81)		0.74 (0.56, 0.96)		0.72 (0.54, 0.97)		0.59 (0.52, 0.82)		0.58 (0.52, 0.84)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.03 (0, 0.068)		0.034 (0, 0.059)		0.012 (0, 0.045)		0 (0, 0.056)		0.023 (0, 0.073)		0.037 (0, 0.087)		0.01 (0, 0.067)		0.016 (0, 0.074)
	Niraparib	count		1		1		1		1		1		1		1		1
		time		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)
		n		2 (2, 2)		5 (5, 5)		3 (3, 3)		4 (4, 4)		3 (3, 3)		3 (3, 3)		4 (4, 4)		2 (2, 2)
		post_p		0.52 (0.52, 0.52)		0.69 (0.69, 0.69)		0.54 (0.54, 0.54)		0.56 (0.56, 0.56)		0.69 (0.69, 0.69)		0.59 (0.59, 0.59)		0.61 (0.61, 0.61)		0.62 (0.62, 0.62)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0.041 (0.041, 0.041)		0 (0, 0)		0.045 (0.045, 0.045)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
		n	10 (10, 10)	1 (1, 1)	5 (5, 5)	8 (8, 8)	5 (5, 5)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	0 (0, 0)	2 (2, 2)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.38 (0.38, 0.38)	0.5 (0.5, 0.5)	0.45 (0.45, 0.45)	0.41 (0.41, 0.41)	0.49 (0.49, 0.49)	0.44 (0.44, 0.44)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.47 (0.47, 0.47)	NA (NA, NA)	0.47 (0.47, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.181 (0.181, 0.181)	0 (0, 0)	0.203 (0.203, 0.203)	0.217 (0.217, 0.217)	0.071 (0.071, 0.071)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.455 (0.455, 0.455)	NA (NA, NA)	0 (0, 0)	0.32 (0.32, 0.32)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
		n	6 (6, 6)	0 (0, 0)	6 (6, 6)	0 (0, 0)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)	3 (3, 3)	2 (2, 2)	1 (1, 1)	4 (4, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)
		post_p	0.29 (0.29, 0.29)	NA (NA, NA)	0.49 (0.49, 0.49)	NA (NA, NA)	0.49 (0.49, 0.49)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	0.39 (0.39, 0.39)	0.43 (0.43, 0.43)	0.46 (0.46, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.281 (0.281, 0.281)	NA (NA, NA)	0.153 (0.153, 0.153)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.695 (0.695, 0.695)	0.452 (0.452, 0.452)	1.037 (1.037, 1.037)	0.108 (0.108, 0.108)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
TP53- & AR-	Hormone_therapies	count	1	1			1	1
		time	7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)
		n	20 (20, 20)	4 (4, 4)			0 (0, 0)	4 (4, 4)
		post_p	0.37 (0.37, 0.37)	0.49 (0.49, 0.49)			NA (NA, NA)	0.44 (0.44, 0.44)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.14 (0.14, 0.14)	0.109 (0.109, 0.109)			NA (NA, NA)	0.067 (0.067, 0.067)
	Taxel_therapies	count	118	118			118	118
		time	14 (9, 27)	14 (9, 27)			14 (9, 27)	14 (9, 27)
		n	23 (16, 45)	4 (1, 8)			5 (2, 10)	4 (2, 8)
		post_p	0.12 (0.01, 0.38)	0.47 (0.37, 0.5)			0.32 (0.08, 0.46)	0.46 (0.34, 0.49)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.157 (0.121, 0.219)	0.081 (0.04, 0.16)			0.166 (0.084, 0.31)	0.058 (0.026, 0.141)
	Carboplatin	count	138	138			138	138
		time	14 (9, 23)	14 (9, 23)			14 (9, 23)	14 (9, 23)
		n	23 (16, 44)	5 (2, 10)			4 (2, 8)	5 (2, 10)
		post_p	0.14 (0, 0.31)	0.33 (0.09, 0.46)			0.46 (0.36, 0.49)	0.44 (0.35, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.155 (0.119, 0.23)	0.169 (0.081, 0.419)			0.085 (0.041, 0.216)	0.053 (0.025, 0.129)
	Niraparib	count	119	119			119	119
		time	13 (9, 20)	13 (9, 20)			13 (9, 20)	13 (9, 20)
		n	22 (15, 37)	5 (2, 9)			4 (1, 8)	4 (2, 10)
		post_p	0.2 (0.02, 0.39)	0.35 (0.17, 0.46)			0.45 (0.39, 0.49)	0.45 (0.37, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.153 (0.116, 0.217)	0.16 (0.085, 0.321)			0.085 (0.047, 0.234)	0.062 (0.031, 0.136)
TP53+	Hormone_therapies	count			237	237			237	237			237	237			237	237
		time			17 (9, 32)	17 (9, 32)			17 (9, 32)	17 (9, 32)			17 (9, 32)	17 (9, 32)			17 (9, 32)	17 (9, 32)
		n			16 (8, 33)	11 (6, 23)			3 (1, 7)	3 (1, 7)			4 (1, 9)	4 (1, 10)			3 (1, 7)	3 (1, 8)
		post_p			0.34 (0.13, 0.48)	0.25 (0.04, 0.44)			0.4 (0.22, 0.48)	0.36 (0.15, 0.47)			0.39 (0.18, 0.49)	0.38 (0.13, 0.47)			0.4 (0.18, 0.47)	0.34 (0.09, 0.46)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.18 (0.139, 0.256)	0.162 (0.115, 0.259)			0.177 (0.082, 0.426)	0.162 (0.077, 0.437)			0.213 (0.136, 0.525)	0.19 (0.114, 0.486)			0.189 (0.103, 0.544)	0.181 (0.077, 0.448)
	Taxel_therapies	count			1	1			1	1			1	1			1	1
		time			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n			10 (10, 10)	9 (9, 9)			2 (2, 2)	0 (0, 0)			0 (0, 0)	2 (2, 2)			3 (3, 3)	3 (3, 3)
		post_p			0.44 (0.44, 0.44)	0.4 (0.4, 0.4)			0.28 (0.28, 0.28)	NA (NA, NA)			NA (NA, NA)	0.44 (0.44, 0.44)			0.17 (0.17, 0.17)	0.5 (0.5, 0.5)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.173 (0.173, 0.173)	0.142 (0.142, 0.142)			0.399 (0.399, 0.399)	NA (NA, NA)			NA (NA, NA)	0.08 (0.08, 0.08)			0.168 (0.168, 0.168)	0.134 (0.134, 0.134)
	Niraparib	count			4	4			4	4			4	4			4	4
		time			11 (10, 16)	11 (10, 16)			11 (10, 16)	11 (10, 16)			11 (10, 16)	11 (10, 16)			11 (10, 16)	11 (10, 16)
		n			13 (12, 14)	8 (4, 10)			2 (1, 4)	0 (0, 1)			4 (3, 6)	4 (2, 6)			1 (0, 3)	2 (1, 4)
		post_p			0.33 (0.29, 0.39)	0.41 (0.13, 0.48)			0.45 (0.34, 0.49)	0.45 (0.42, 0.49)			0.44 (0.33, 0.48)	0.32 (0.14, 0.36)			0.48 (0.48, 0.49)	0.45 (0.42, 0.45)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.207 (0.177, 0.255)	0.102 (0.081, 0.307)			0.129 (0.026, 0.187)	0.674 (0.135, 1.212)			0.206 (0.152, 0.244)	0.194 (0.132, 0.312)			0.064 (0.06, 0.069)	0.157 (0.066, 0.53)
DRD+	Hormone_therapies	count					116	116	116	116					116	116	116	116
		time					19 (13, 26)	19 (13, 26)	19 (13, 26)	19 (13, 26)					19 (13, 26)	19 (13, 26)	19 (13, 26)	19 (13, 26)
		n					5 (2, 12)	5 (2, 11)	4 (2, 6)	3 (1, 7)					4 (2, 7)	4 (1, 7)	4 (1, 7)	3 (1, 7)
		post_p					0.45 (0.3, 0.49)	0.43 (0.28, 0.49)	0.36 (0.2, 0.48)	0.34 (0.16, 0.46)					0.36 (0.16, 0.47)	0.34 (0.14, 0.45)	0.37 (0.16, 0.47)	0.35 (0.17, 0.45)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.072 (0.048, 0.158)	0.053 (0.032, 0.13)	0.183 (0.083, 0.426)	0.179 (0.088, 0.391)					0.178 (0.092, 0.471)	0.169 (0.1, 0.417)	0.186 (0.102, 0.577)	0.165 (0.075, 0.57)
	Taxel_therapies	count					10	10	10	10					10	10	10	10
		time					16 (13, 24)	16 (13, 24)	16 (13, 24)	16 (13, 24)					16 (13, 24)	16 (13, 24)	16 (13, 24)	16 (13, 24)
		n					8 (4, 10)	7 (2, 10)	4 (2, 6)	3 (1, 5)					5 (3, 7)	4 (2, 9)	4 (0, 8)	4 (2, 5)
		post_p					0.22 (0.12, 0.47)	0.4 (0.29, 0.49)	0.4 (0.18, 0.47)	0.44 (0.37, 0.48)					0.34 (0.28, 0.48)	0.46 (0.41, 0.49)	0.33 (0.21, 0.4)	0.43 (0.3, 0.5)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.184 (0.093, 0.275)	0.082 (0.049, 0.162)	0.171 (0.153, 0.416)	0.067 (0.045, 0.184)					0.204 (0.095, 0.356)	0.08 (0.06, 0.193)	0.225 (0.164, 0.309)	0.094 (0.015, 0.142)
TEfus+	Hormone_therapies	count		107		107		107		107		107		107		107		107
		time		16 (11, 33)		16 (11, 33)		16 (11, 33)		16 (11, 33)		16 (11, 33)		16 (11, 33)		16 (11, 33)		16 (11, 33)
		n		5 (2, 10)		10 (6, 18)		5 (2, 11)		3 (1, 7)		5 (2, 9)		4 (1, 8)		3 (1, 7)		3 (1, 7)
		post_p		0.44 (0.31, 0.49)		0.21 (0.05, 0.44)		0.44 (0.31, 0.49)		0.37 (0.15, 0.45)		0.36 (0.15, 0.45)		0.38 (0.15, 0.48)		0.32 (0.12, 0.45)		0.35 (0.09, 0.45)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.091 (0.053, 0.223)		0.173 (0.118, 0.268)		0.054 (0.03, 0.131)		0.183 (0.09, 0.46)		0.189 (0.109, 0.39)		0.196 (0.101, 0.768)		0.177 (0.092, 0.421)		0.188 (0.088, 0.423)
	Carboplatin	count		14		14		14		14		14		14		14		14
		time		16 (13, 28)		16 (13, 28)		16 (13, 28)		16 (13, 28)		16 (13, 28)		16 (13, 28)		16 (13, 28)		16 (13, 28)
		n		5 (2, 11)		9 (5, 12)		5 (3, 9)		4 (0, 5)		4 (2, 8)		4 (2, 7)		3 (2, 7)		3 (1, 6)
		post_p		0.24 (0.08, 0.41)		0.24 (0.15, 0.39)		0.46 (0.36, 0.48)		0.44 (0.27, 0.49)		0.39 (0.2, 0.48)		0.29 (0.09, 0.44)		0.45 (0.33, 0.47)		0.44 (0.39, 0.49)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.205 (0.111, 0.358)		0.156 (0.097, 0.182)		0.044 (0.029, 0.113)		0.071 (0.032, 0.134)		0.137 (0.084, 0.376)		0.175 (0.117, 0.403)		0.104 (0.051, 0.165)		0.138 (0.04, 0.384)
	Niraparib	count		13		13		13		13		13		13		13		13
		time		14 (12, 26)		14 (12, 26)		14 (12, 26)		14 (12, 26)		14 (12, 26)		14 (12, 26)		14 (12, 26)		14 (12, 26)
		n		3 (3, 5)		11 (8, 24)		4 (2, 9)		3 (0, 4)		4 (2, 9)		5 (2, 9)		2 (0, 11)		3 (0, 5)
		post_p		0.3 (0.13, 0.45)		0.12 (0.01, 0.32)		0.43 (0.27, 0.49)		0.44 (0.4, 0.48)		0.41 (0.24, 0.48)		0.39 (0.18, 0.46)		0.42 (0.36, 0.49)		0.42 (0.34, 0.46)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.147 (0.094, 0.387)		0.164 (0.132, 0.255)		0.062 (0.044, 0.132)		0.065 (0.021, 0.256)		0.21 (0.144, 0.344)		0.206 (0.113, 0.261)		0.131 (0.079, 0.401)		0.118 (0.042, 0.653)